kainate receptor การใช้

• Synaptic transmission and hippocampal plasticity are both affected by kainate receptors.
• It is selective for kainate receptors composed of GluR5 subunits.
• Kainate receptors are thought to be involved in epileptic activity.
• AMPA and Kainate receptors are regulated by SGK isoforms.
• The Q / R site also occurs in the Kainate receptors GluR5 and GluR6.
• The specific GluR subunit encoded by this gene is of the kainate receptor subtype.
• Kainic acid is an agonist for kainate receptors, a type of ionotropic glutamate receptor.
• It damages the neurons by activating AMPA and kainate receptors, causing an influx of calcium.
• NBQX blocks AMPA receptors in micromolar concentrations ( ~ 10 20 礛 ) and also blocks kainate receptors.
• Kainate receptors likely control a sodium channel that produces excitatory postsynaptic potentials ( EPSPs ) when glutamate binds.
• In the hippocampus, GABAergic neurons have been found vulnerable to excitotoxic action of glutamate at the kainate receptor.
• It has later been shown that dPTX targets calcium permeable AMPA receptor and kainate receptor but not NMDA receptor.
• Diazoxide acts as a positive allosteric modulator of the AMPA and kainate receptors, suggesting potential application as a cognitive enhancer.
• A fourth class, known as kainate receptors, are similar in many respects to AMPA receptors, but much less abundant.
• The other LTD mechanism involves acetylcholine receptors and kainate receptors at a much earlier time, about 20 to 30 minutes after stimulus.
• It is useful to isolate the action of other glutamate receptors in the brain, i . e ., AMPA and kainate receptors.
• "' UBP-302 "'is a highly selective kainate receptor antagonist used in the study of many neurological processes.
• Kainic acid is a direct agonist of the glutamic kainate receptors and large doses of concentrated solutions produce immediate neuronal death by overstimulating neurons to death.
• "' 5-Fluorowillardiine "'is a selective agonist for the AMPA receptor, with only limited effects at the kainate receptor.
• "' 5-Iodowillardiine "'is a selective agonist for the kainate receptor, with only limited effects at the AMPA receptor.